Tabriz University of Medical Sciences Pharmaceutical Sciences 1735-403X 32 1 2026 01 07 Recent Advances in Wafer Delivery: Chemistry, Manufacturing, and Control 42 57 10.34172/PS.026.40987 EN Ali Rajabi Zangi https://orcid.org/0009-0000-0496-0517 Ali Azizi Fatemeh Soltanmohammadi Zohreh Asadi Mohammad Sheibani Yousef Javadzadeh https://orcid.org/0000-0001-7283-3560 REVIEW 10.34172/PS.026.40987 2024 11 20 2025 05 28 Wafer drug delivery offers a promising approach to personalized medicine by enabling precise dosage adjustments, controlled release rates, and tailored drug responses. By carefully selecting the composition, wafers can optimize therapeutic outcomes for individual patients. The development of a wafer formulation involves choosing the appropriate active ingredients, excipients, and drug compounds, which directly impact stability, solubility, and release profile of the drug. This study addresses the essential components and characteristics required for formulating an optimized wafer product, alongside the critical control steps necessary for its evaluation. Additionally, the manufacturing process plays a key role in maintaining quality standards by ensuring consistent drug content, uniformity, and dissolution properties. Ultimately, thorough characterization and monitoring of wafer quality are vital to guarantee safety, efficacy, and stability. We begin by reviewing ongoing clinical trials and existing products currently available in the wafer market.