Tabriz University of Medical Sciences Pharmaceutical Sciences 1735-403X 28 3 2022 07 27 Antioxidant Activity and Nano Delivery of the Most Frequently Applied Stilbene Derivates: A Brief and Recent Review 365 375 10.34172/PS.2021.71 EN Syaiful Choiri https://orcid.org/0000-0001-7750-6008 Rafifah Fitriastuti Firdausi Z. Faradiva Windy V. Rahayu REVIEW 10.34172/PS.2021.71 2021 06 06 2021 11 21 As of recent, the appearance rate of several degenerative diseases and cancer influenced by oxidative stress continues to increase dramatically. Many compounds with high potential antioxidant activity have been explored and used extensively, i.e., as preventive or curative treatments. Stilbene and its derivates have high potential antioxidant activity contained in several botanical sources. To date, source exploration and antioxidant activity study of stilbene derivate has been reported. However, the nano-delivery of stilbene derivate meant to increase the antioxidant activity and stability is still a limited process. This review is devoted to brief and recent outlooks regarding the antioxidant activity and delivery system of the most frequently applied stilbene and its derivates, namely resveratrol and pterostilbene.